Joey has struck out on his own and moved to Hollywood, hoping to truly make it as an actor. Joey says goodbye to a time when his friends were his family and welcomes the chance to turn his family into his friends. After reuniting with his high-strung sister Gina, a strong and sexy hairdresser, Joey moves in with her genius 20-year-old son, graduate student Michael, who literally is a rocket scientist. What Joey lacks in book smarts, however, he more than makes up for with his people skills, making him the best new friend his nephew could ask for.
Joey meets Deep Powder's executive producer, Lauren Beck. Joey worries that he may be fired after giving away a plot twist at a press conference. Alex, Gina and Michael decorate the apartment for Joey for Christmas.
Joey's relationship with costar Katie has consequences that could get him fired from the show, unless he manages to talk her out of her dressing room. Joey and Lauren acknowledge their feelings for one another. After Gina teaches Alex how to make lasagna, Joey is forced to judge a taste test.
Unable to decide who to take to the premiere of Deep Powder, Joey struggles to find tickets for Gina, Michael and Alex. Michael meets a girl and Brent Spiner and must choose who to leave with. Gina's date is Lauren's ex-boyfriend. Alex's date is a lesbian. Joey and Lauren kiss.
Following Bobbie's advice to get an assistant, Joey winds up with Glen, who couldn't be better. But when Glen starts dating Gina, his worlds colliding means problems for Joey. Eventually, Gina and Joey create some guidelines so that Glen can continue working for both of them. Meanwhile, Alex mediates Michael's dispute over a patent with his friend Seth.
Bobbie has booked Joey on The Tonight Show with Jay Leno. En route to the show, he's stuck in a major traffic jam. After giving the finger to a guy who cut him off, Michael is terrified after they are stuck next to the guy's car. Gina meets two guys, one in an El Camino and one in a Mercedes. Alex saves the day when she shows up with a motorcycle that gets Joey onstage and hugging Jay Leno just in time.
Joey accidentally makes a date with a reporter from "People" for Valentine's Day. He has the gang "accidentally" bump into him and his date at the restaurant to ruin the mood, but his plans backfire when she thinks he's taking their relationship to the next level. A drunken Alex shares some sexual secrets with Gina. After Joey sends Michael over to hit on a table of girls, Michael actually becomes "one of the girls."
